Abstract
The aim of the current study was to investigate the morphological and histological effects of Bisphenol A on chicken Ross 308 during embryonic development A total of 150 eggs were randomly divided into five groups: negative control, positive control injected with con oil and treatment groups administered with different concentrations of Bisphenol A (0.005, 0.02 and 0.1 microliters/egg). The eggs were injected on the second day of incubation and the evaluation was conducted on days 10 and 21 of incubation. Our results showed different abnormal observations at both ages of incubation including skin redness, presence of hemorrhagic spots on the head and around the eyes, congenital anomalies in the upper and lower limbs, chick lethargy and inflammation, particularly in the caudal region. Additionally, there was a clear paralysis in a chicken aged 21 days. Microscopically, there were changes in the liver structure representing congestion in the central vein, mild focal intercellular changes in hepatocytes, few necrosis and atrophy of hepatic cords. At day 21, there was also dispersed hemorrhagic, inflammatory infiltration slight proliferation of Kupffer cells, fatty degeneration, irregularity of hepatocytes and hepatic cords as well as cloudy swelling.
References
Abdel-Rahman, H.G., Abdelrazek, H., Zeidan, D.W., Mohamed, R.M., Abdelazim, A.M. (2018). Lycopene: hepatoprotective and antioxidant effects toward Bisphenol A-induced toxicity in female Wistar rats. Oxidative Medicine and Cellular Longevity, 2018,1-8. ?
Ahmed Zaki, M.S., Haidara, M.A., Abdallaa, A.M., Mohammed, H., Sideeg, A.M., Eid, R.A. (2021). Role of dietary selenium in alleviating Bisphenol A toxicity of liver albino rats: Histological, ultrastructural, and biomarker assessments. Journal of Food Biochemistry, 45(5), e13725. ?
Al-Jomily, Z., Al-Sultan, R. (2022). Effect of nanoscale titanium dioxide on quail testes tissue and molecular diagnosis in RABD_PCR Method. HIV Nursing, 22(2), 2236-2239.
Najjar, R.A., Abed, F.M., Alsultan, R.G. (2022). Effect of Bisphenol A on hearts of pregnant mice and their fetuses. Indian Veterinary Journal, 99(12), 27–34.
Al-Mustafa, S.S., Al-Sultan, R.G. (2022), Histological changes of liver and lung induced by Bisphenol a in pregnant mice. International Journal of Drug Delivery Technology, 12(2), 678-681
Al-Sultan, R.G., Ismail, H.Kh, AL-Baker, A.A. Alkafaf, A.I. (2023). The effect of acute toxicity of zinc oxide nano-particles on the male albino rats. Malaysian Applied Biology, 52(4), 1-6.
Arrigo, A.P. (1999). Gene expression and the thiol redox state. Free Radical Biology and Medicine, 27(9-10), 936-944. ?
Atay, E., Ertekin, A. Bozkurt, E., Aslan, E. (2020). Impact of Bisphenol A on neural tube development in 48?hr chicken embryos. Birth Defects Research, 112(17), 1386-1396.
Ate?, M.B., Hatipo?lu, D. (2022). Effect of nigella sativa oil on Bisphenol a-induced hepatotoxicity in Wistar albino rats: histopathological and biochemical investigation. International Journal of Agriculture Environment and Food Sciences, 6(3), 402-409. ?
Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., Oriente, F. (2020). Potential mechanisms of Bisphenol A (BPA) contributing to human disease. International journal of molecular sciences, 21(16), 5761. ?
Cohen, I.C., Cohenour, E.R., Harnett, K.G., Schuh, S.M. (2021). BPA, BPAF and TMBPF alter adipogenesis and fat accumulation in human mesenchymal stem cells, with implications for obesity. International Journal of Molecular Sciences, 22(10), 1-17.
Culling, C.F.A., Allison, R.T., Barr, W.T. (1985). Cellular pathology technique. 4thed. Mid-country press, London Sw15, 135-159.
Faheem, M., Khaliq, S., Lone, K.P. (2019). Effect of Bisphenol-A on serum biochemistry and liver function in the freshwater fish, Catla catla. Pak. Vet. J, 39(1), 1-5.
Harnett, K.G., Moore, L.G., Chin, A., Cohen, I.C., Lautrup, R.R., Schuh, S.M. (2021). Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development. Current Research in Toxicology, 2, 399-410.
Lopes?Rocha, L., Ribeiro?Gonçalves, L., Henriques, B., Özcan, M., Tiritan, M.E., Souza, J.C. (2021). An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 109(11), 1942-1952.
Ma, Y., Liu, H., Wu, J., Yuan, L., Wang, Y., Du, X., Zhang, H. (2019). The adverse health effects of Bisphenol A and related toxicity mechanisms. Environmental Research, 176, 108575. ?
Maffini, M.V., Canatsey, R.D. (2020). An expanded toxicological profile of tetramethyl Bisphenol F (TMBPF), a precursor for a new food-contact metal packaging coating. Food and Chemical Toxicology, 135, 110889.
Petrie, B., Lopardo, L., Proctor, K., Youdan, J., Barden, R., Kasprzyk-Hordern, B. (2019). Assessment of Bisphenol-A in the urban water cycle. Science of the Total Environment, 650, 900-907.
Ribeiro, E., Ladeira, C., Viegas, S. (2017). Occupational exposure to Bisphenol A (BPA): a reality that still needs to be unveiled. Toxics, 5(3), 22. ?
Rogers, K. (2021) "Bisphenol A". Encyclopedia Britannica, https://www.britannica.com/science/Bisphenol-A
Salamanca-Fernández, E., Rodríguez-Barranco, M., Amiano, P., Delfrade, J., Chirlaque, M.D., Colorado, S., Sánchez, M.J. (2021). Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study. Environmental Health, 20(1), 1-12.
Shackelford, R.E., Kaufmann, W.K., Paules, R.S. (2000). Oxidative stress and cell cycle checkpoint function. Free Radical Biology and Medicine, 28(9), 1387-1404.
Sharma, M., Sharma, R., Gupta, P., Srivastava, S. (2019). Bisphenol-A induced oxidative stress and its fertility aspects. International Journal of Pharmaceutical Sciences and Research, 10, 3519-31. ??
Somm, E., Schwitzgebel, V. M., Toulotte, A., Cederroth, C. R., Combescure, C., Nef, S., and Hüppi, P. S. (2009). Perinatal exposure to Bisphenol A alters early adipogenesis in the rat. Environmental Health Perspectives, 117(10), 1549-1555. ?
?Suvarna, S.K., Layton, C., Bancroft, J.D. (2019). Bancroft's theory and practice of histological techniques, 8th ed. 40-535.
Suzuki, Y.J., Forman, H.J., Sevanian, A. (1997). Oxidants as stimulators of signal transduction. Free Radical Biology and Medicine, 22(1-2), 269-285. ?
Taha, B.A., Mohammed, R.H. (2022). Investigation the toxicity of compound insecticide (Acetamiprid and Thiamethioxam) on development of Ross 308 broiler chick embryo. Journal of Education and Science, 31(1), 123-136.
Tonini, C., Segatto, M., Bertoli, S., Leone, A., Mazzoli, A., Cigliano, L., Pallottini, V. (2021). Prenatal exposure to BPA: The effects on hepatic lipid metabolism in male and female rat fetuses. Nutrients, 13(6), 1-14.
Xiao, C., Wang, L., Zhou, Q., Huang, X. (2020). Hazards of Bisphenol A (BPA) exposure: A systematic review of plant toxicology studies. Journal of Hazardous Materials, 384, 121488.
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